منابع مشابه
Vascular gene transfer : from bench to bedside.
Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene trans...
متن کاملSelective Adenovirus-Mediated Gene Transfer Into Vascular Neointima
18. Simons M, Rosenberg RD. Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro. Circ Res. 1992;70:835-843.19. Biro S, Fu YM, Yu ZX, Epstein SE. Inhibitory effects of antisenseoligodeoxynucleotides targeting c-myc mRNA onsmooth musclecell proliferation and migration. Proc Nadl Acad Sci U S A.1993;
متن کاملImproved vascular gene transfer with a helper-dependent adenoviral vector.
BACKGROUND Adenoviral vectors are the most widely used agents for vascular gene transfer. However, the utility of adenoviral vectors for vascular gene transfer is limited by brevity of expression and by the induction of a significant host inflammatory response. Third-generation or "helper-dependent" adenoviral vectors have achieved prolonged recombinant gene expression in liver and muscle with ...
متن کاملVascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer.
We have reported that adenovirus-mediated gene transfer is augmented in the endothelium of atherosclerotic blood vessels. We observed that vascular cell adhesion molecule-1 (VCAM-1) shares some homology with the coxsackievirus and adenovirus receptor. Because VCAM-1 is upregulated on atherosclerotic endothelial cells, we hypothesized that VCAM-1 may act as an auxiliary receptor to augment adeno...
متن کاملLiposome-mediated gene transfer into human vascular smooth muscle cells.
BACKGROUND Complexing recombinant DNA with cationic liposomes is a convenient means of introducing foreign genes into cells (lipofection) and could potentially form the basis for genetically modifying diseased blood vessels in patients. The mechanism of lipofection is incompletely understood, but it is recognized that the degree of successful gene transfer is highly dependent on cell type. To d...
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ژورنال
عنوان ژورنال: Heart
سال: 1996
ISSN: 1355-6037
DOI: 10.1136/hrt.75.3.215